Thesis anticancer agents

Synthetic strategies for the design of platinum anticancer drug candidates

In addition, there are several examples of promising natural product-derived antineoplastic agents currently in advanced clinical development or recently approved, not only from microbes e. Following activation, the ULK1 complex relays signals for the recruitment of other Atg pro- teins to autophagosome formation sites on cellular membranes, including the endoplasmic reticulum Figure These results implicate mitophagy autophagy of mitochondria and mitochondrial degra- dation in the mechanisms of ceramide-induced ACD.

A hydro alcohol extract of Daphne mezereumhas exhibited a potent antileukemic activity against lymphocytic leukemia in mice. This chapter presents a comprehensive review of synthetic methods for the preparation of classic and non-conventional platinum compounds with therapeutic potential.

Using the in vivo hollow fiber model, alvaradoin E demonstrated significant growth inhibition at the i. Hydrocotyle Asiatica Hydrocotyle asiatica is the scientific name of Gotu kola, brahmi, synonyms with Centella asiatica.

However, one approach towards enhancing the solubility of pancratistatin has been to produce its sodium pancratistatin 3,4-O-cyclic phosphate salt 4as reported by Pettit and colleagues in [ 43 ].

Again, though, as stated above, it should be considered that inhibitors of the lysosomal activity that are commonly used to prove autophagic flux i. A mitodeprssive effect was observed on the rate of cell division in bone marrow of Swiss mice, which was attributed to the effect of inhibiting protein synthesis [ 79 ].

Combined treat- ment was sufficient to restore dexamethasone response in GC-resistant acute lymphocytic leukemia cells. By reducing the oxidized product [Pt edDs C14] with an excess of the biological reducing agents glutathione, cysteine, and ascorbic acid in aqueous buffer, a 6.

Several mechanisms were proposed to explain the toxic effects of autophagy during ACD. Silymarin was studied against UV radiation induced skin cancer in mice.

Petroleum ether and ethyl acetate extracts of Nervilia fordii has been screened out for its anticancer properties using mice models.

Platinum II Complexes Bearing Fluorescent DiPyridylmethane Ligands A strategy to investigate the cellular uptake and localization of platinum anticancer agents is to label them with a fluorescent ligand.

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Hypericum perforatum inhibitory activity was due to its components, whichinhibits serotoninreuptake and thus reduces cell growth on several cancer cell lines, in vitro and in vivo [ 63 ]. This would then be tested against a number of human cancer cells, such as the U.

Kelley at the University of Toronto to deliver platinum anticancer agents to the mitochondria are presented. These results can be useful for the development of new efficient telomerase inhibitors which are endowed with pharmacological activity.

Microarray and pathway analysis of tumor related genes identified the differentially expressed genes responding to tanshinone I and suggest that tanshinone I exhibits anticancer effects both in vitro and in vivo [ 86 ].

Synthetic strategies for the design of platinum anticancer drug candidates

Crystal structures are described for several of them. Further investigations on tubeimoside-V revealed the apoptotic killing nature on glioblastoma cells, thus suggesting its critical role in antitumor chemotherapy [ 36 ].

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Full stereostructures were reported for pericosines C-E, three further analogs of periocosines A and B, and it was indicated that 5 inhibits protein kinase EGFR and topoisomerase II [ 46 ]. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Mollugin has shown a significant activity against lymphoid leukemia in mice and also showed the inhibition of passive cutaneous anaphylaxis, protection of mast cells degranulation in rats [ 78 ].

Recently, silvestrol was found to occur in the leaves of one of its plants of origin, A. As a result, an increase in free BECN1 levels in cells seems to favor the stimulation of autophagy. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with WS.

A number of side effects accompany platinum-based therapy and novel approaches are under investigation to attenuate these negative effects and circumvent tumor resistance, be it inherent or acquired. G-quadruplex structures are found in important regions of the eukaryotic genome, such as telomeres and regulatory sequences of genes, and are likely to play important roles in regulation of biological events.

The significant structural differences with duplex DNA make quadruplex DNA a very attractive target for anticancer drug design. anti-cancer agents. The research will be focused on the significance of natural products towards the manufacturing of anti-cancer agents and how plants in Annonaceae family are facilitating the pharmaceuticals in discovering new ways to combat the symptoms of cancer.

Discovery of Natural Product Anticancer Agents from Biodiverse Organisms

My thesis includes the development of two novel anticancer agents based on natural products; OSW-1 analog (ZJ) and truncated Superstolide A analog (ZJ). OSW-1 is isolated from the bulbs of Ornithogalum saundersiae. Thesis Submitted in Partial Fulfilment Of the Requirements for the Degree of [Name of program] [Name of University] [Last month of quarter you plan to graduate] 20XX.

Natural Product as Anti-Cancer Agent 2 anti-cancer agents has been extensively discussed in academic resources.

Developments in the chemistry and nanodelivery of platinum anticancer agents

There are many natural. SCHWEINFURTHINS AS NOVEL ANTICANCER AGENTS by Craig Heath Kuder UAn Abstract Of a thesis submitted in partial fulfillment of the requirements for the Doctor of.

These days most of the research work on cancer drugs is targeted on plants and plants derived natural products. Many natural products and their analogues have been identified as potent anti-cancer agents and day by day the anti-cancer property of various plants is being identified.

Thesis anticancer agents
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